Sesamol

Sesamol foda Bayanan Basan

sunan	Sesamol foda
Bayani	White foda
CAS	533-31-3
kima	≥99%
solubility	kusanluble cikin ruwa ko giya, mai narkewa a cikin Acetic acid, etyl ester.
Taro na Molar	138.12 g / mol
Marin Matsa	62 zuwa 65 ° C (144 zuwa 149 ° F; 335 zuwa 338 K)
kwayoyin Formula	C7H6O3
tafasar batu	21 zuwa 127 ° C (250 zuwa 261 ° F; 394 zuwa 400 K) a 5
SMILES	mmHgO1c2ccc (O) cc2OC1

 

Menene Sesamol?

Sesamol wani sinadari ne na halitta wanda aka samo shi a cikin sarrafawar sesame da gasasshen iri. Sesamol (CAS 533-31-3) ana ɗauke da babban mai aiki da ƙarfi na sesame wanda ke taka rawa wajen tasirin maganin sa.

Sesame (Sesamum nuni) shine mai mahimmin mai a cikin iyali Pedaliaceae. Ana ɗaukarsa ɗayan tsoffin maɗaukakin man da aka sani kuma mutum yana amfani da shi don ƙimar ƙimar abincinsa kawai har ma da magani. Babban ɓangaren sesame wanda ke ba da ƙimar magani shine ganye da mai iri.

Ana samun sinadarin Sesamol 533-31-3 da yawa ba tare da wasu sinadaran lignin na man sesame, sesamin da sesamolin ba. Wannan mahaɗin mai narkewa na ruwa yana ɗaukar antioxidant mai ƙarfi.

 

Yaya sesamol work?

Sesamol yana aiki ta hanyoyi daban-daban don bayar da fa'idodi masu yawa na warkewa kamar su neuroprotection, sakamakon antioxidant, anti-inflammatory, anti-tumo, anti-radiation da radical scavenging effects.

Da ke ƙasa akwai wasu hanyoyi waɗanda sesamol ke aiki don cimma fa'idar da aka faɗi;

 

I. Yana hana lalacewar DNA ta damun rashi

Sesamol na iya hana lalacewar DNA ta damuwa mai haifar da iska. Radiationonon radiation yana haifar da lalacewa ga DNA ta salula ta hanyar haifar da haɓakar chromosomal da micronuclei a cikin ƙwayoyin halitta masu haɓaka.

 

II. Yana motsa ayyukan mahimman antioxidants

Sesamol yana aiki ta hanyar tsara ayyukan muhimman enzymes masu maganin antioxidant kamar catalase (CAT), superoxide dismutase (SOD), da glutathione peroxidase (GPx), wanda ke tare da ƙarin matakan rage yawan abinci (GSH). Wadannan enzymes suna taka muhimmiyar rawa wajen hana lalacewar salula ta hanyar masu tsattsauran ra'ayi.

 

III. Dakatar da sunadaran pro-apoptotic don haka haɓaka haɓakar kwayar halitta

Pro-apoptotic sunadaran sunadaran da ke inganta mutuwar kwayar halitta. Sun hada da p53, caspase-3, PARP, da Bad enzymes. Waɗannan enzymes suna cikin ƙwayoyin salula wanda aka tsara don haka zai iya rage ƙwayoyin salula.

Sesamol an nuna shi don haɓaka ƙwayoyin salula ta hanyar hana aikin enzymes na pro-apoptotic.

 

IV. Haramtawa na peroxidation na lipid

Peroxidation na Lipid wani nau'i ne na lalacewar lipid da ke faruwa saboda hadawan abu. Wannan yana haifar da samuwar aldehydes mai amsawa, kamar malondialdehyde (MDA) da 4-hydroxynonenal (HNE) wanda ke haifar da lalacewar kwayar halitta. Sesamol an nuna shi don hana peroxidation na lipid don haka yana ba da kariya ga ƙwayoyin.

 

V. Yana hana ƙarni na 'yanci kyauta ciki har da masu tsattsauran ra'ayi na hydroxyl

Abubuwan 'yan' yanci na kyauta sune mahaɗan marasa ƙarfi waɗanda ke da alaƙa da cututtuka da tsufa. Hydroxyl radicals sune mafi ƙarfin oxidants waɗanda ke haifar da rashin lafiya.

Sesamol yana rage ƙarni na masu rajin kyauta ciki har da hydroxyl, α, α-diphenyl-β-picrylhydrazyl (DPPH), da ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) masu tsattsauran ra'ayi.

 

VI. Inganta ayyukan rarar tsattsauran ra'ayi

Bugu da ƙari ga hana ƙarni na free radicals, sesamol na iya kawar da masu kwayar cutar masu kyauta kamar hydroxyl, lipid peroxyl da tryptophanyl radicals.

 

VII. Danniyar kwayoyin cuta

Sesamol yana hana hanyoyin siginar da ke tattare da samar da nau'in halittu masu tasiri don haka yana rage radadin kumburi.

 

Sabunta. Rage cytokines mai kumburi (TNFα, IL-1β, da IL-6)

Nitric oxide, wanda iNOS ya samar, yana haifar da kumburin huhu ta hanyar motsa cytokines mai kumburi, kamar TNFα, da haɓaka haɓakar mai kumburi. Sesamol yana da ikon hana sakin TNFα da IL-1β.

 

IX. Kama kama da girman kwayar halitta a matakai daban-daban

Sesamol an nuna shi don haifar da kama kwayar halitta a matakai daban daban na ci gaban kwayoyi ciki harda S phase da G0 / G1 phase. Saboda haka dukiyar Sesamol anti cancer tana taimakawa, alal misali, rage ci gaban kwayar cutar kansa.

 

X. Kunna hanyar hanyar caspase

Caspases din sune enzymes wadanda suke cikin mutuwar kwayar halitta. An nuna Sesamol don kunna waɗannan hanyoyin don haka yana haifar da mutuwar kwayar cutar kansa.

 

XI. Apoaddamar da apoptosis ta hanyar hanyoyi masu mahimmanci

Apoptosis tsari ne na ilimin lissafi wanda ake samun mutuwar kwayar halitta mai rai. Yana da mahimmin tsari tunda yana taimakawa jiki cire ƙwayoyin rai da suka mutu.

Sesamol yana haifar da apoptosis ta hanyoyi daban-daban guda biyu, na musamman da kuma na waje.

 

XII. Ersan Indiya mitophondrial autophagy

Mitochondrial autophagy wani nau'i ne na ƙasƙanci wanda ke taimakawa kawar da mitochondria mai lahani.

Lokacin da sesamol ya hana wannan aikin, to an haifar da apoptosis.

 

XIII. Rage matakan nitrite da neutrophil

Nitrites da neutrophils suna taka rawa a cikin martani mai kumburi. Suna da hannu cikin sakin nitric oxide wanda ke sassaucin amsawar mai kumburi ta hanyar haifar ko kuma hana kumburi.

Sesamol yana taka rawa a matsayin wakili mai kare kumburi ta rage matakan nitrites da neutrophils.

 

Menene sesamol da ake amfani da shi?

Ana amfani da Sesamol don amfanin kiwon lafiya daban-daban da suka hada da;

 

i Hawan jini.

Ana amfani da man Sesame tare da wasu drugsan kwayoyi masu hawan jini azaman magani da aka tabbatar don rage hawan jini.

Wide bincike akan man sesame ya nuna cewa sesamol da sesamin (lignans da ake samu a cikin sesame oil) suna taka rawa babba wajen daidaita hawan jini. Shan mai na sesame, yafi dafa shi dashi, tsawon sati uku yana saukar da hawan jini ga mutanen da ke fama da hauhawar jini zuwa al'ada.

Yayin binciken, likitocin kiwon lafiya sun sanya gungun marasa lafiya masu hawan jini zuwa magunguna (Procardia, Nefedica da Adelta) na tsawon kwanaki 21. Kodayake an ɗan ɗan rage matsa lamba na jininsu, amma bai daidaita ba. An yi amfani da man Sesame a matsayin maye gurbin magunguna, kuma an gwada marasa lafiya bayan wannan lokacin. Sakamakon ya kasance cewa karfin jininsu ya fadi daidai.

Likitocin sunyi jayayya cewa sakamakon ya bada gudummawa sosai ta yawan sesamol da sesamin a cikin dafaffen mai na sesame. Idan haka ne aka gano cewa har da mai na sesame a cikin abinci ga masu cutar hawan jini zai iya zama mai tasiri fiye da batun sa musu magani.

Wadannan sakamakon sun bayar da rahoton ne ga Kungiyar Zuciya ta Amurka yayin taron shekara-shekara na -ungiyar Haɗin Haɗin Haɗin Amurka da Farfesa Devarajan Sankar na Jami'ar Annamalai, Indiya.

 

ii. Toshewa a cikin hanji.

Bincike kan tasirin sesamol akan toshewar hanji yana nuna cewa zai iya zama mafi kyau fiye da asfirin. A kan wani bincike game da ciwon ulcerative colitis, wani IBD (cututtukan hanji mai kumburi), wanda ke haifar da lahani ga ƙwayar tsoka ta hanyar lalata tsarin mai kumburi. A wani binciken da ya shafi beraye, an gano sesamol don rage ayyukan enzymes masu haifar da kumburi.

Kodayake sanannen asfirin yana kashe cututtukan kumburi yadda yakamata idan aka sha, amma hakan na iya haifar da ciwan gyambon ciki a tsawon lokaci. Asfirin yana haifar da raunin ciki ta hanyar ƙarancin ƙwayoyin halitta.

Researcharin bincike yana nuna cewa nasogastric intubation na sesamol a cikin marasa lafiya da ke fama da ƙananan hanji tare da kulawa ta yau da kullun yana rage damar fuskantar tiyata.

 

iii. Ciwon zuciya.

Abubuwa masu haɗari waɗanda cututtukan zuciya da jijiyoyin jini suka danganta suna da babban rabo a cikin mace-mace da cutar ta duniya. Zasu iya haifar da danniya na rashin kuzari kuma idan ba a magance shi ba ya ta'azzara zuwa haɓakar samar da pf mai amfani da nau'in oxygen, gami da gurɓataccen tsarin kare garkuwar jiki.

Sesamol yana amfani da sinadarin anti-oxidative don hana cututtukan atherosclectoric cututtukan zuciya da cututtukan haɗari kamar su hypercholesterolemia, hypertriglyceridemia, yawan tattara ƙwayoyin cholesterol na low-density da low lipoprotein.

Arin bincike ya kammala da cewa sesamol yana da matattarar membrane da rage tasirin lipid. Bugu da ƙari, yana ba da kariya ga myocardium game da cututtukan zuciya da ke haifar da cutar ta DOX.

 

IV. Ci gaban yaro.

Ana amfani da Sesamol a fannoni daban-daban na haɓakar yara. A cikin karatu daban-daban, sesamol da aka yi amfani da shi don rage ADHD a cikin yara masu larurar hankali an kira su da ɗan tasiri in an yi amfani da su kaɗan. Rashin DHA ya zama ruwan dare gama gari ga yara masu fama da ADHD.

Fiye da bincike goma suna nuna fa'idodi masu fa'ida a cikin alamun ADHA gami da karanta kalmomin, impulsivity, koyon gani, ƙwaƙwalwar aiki, da haɓakawa.

Yaran da aka tausa akan mai na sesame na tsawon makonni huɗu sun sami ingantaccen ci gaba da motsa jiki.

 

v. Ciwon sukari.

Sesamol yana aiki yadda yakamata azaman kari ga maganin ciwon suga don rage matakan sukarin jini cikin sauri. Shan abubuwan karin sinadarin sesamol ko kuma sauyawa zuwa abincin mai na sesame yayin da kwayoyi masu ciwon sikila ke ba da kyakkyawan sakamako ga aikin.

A cikin bincike da yawa, yawancin waɗanda suka shafi marasa lafiya na ciwon sukari na 2, sesamol sun nuna babban sakamako. Ofaya daga cikin karatun ya ƙunshi ƙungiyoyi uku, kowanne yana fama da ciwon sukari na 2. Groupaya daga cikin ƙungiyoyi sun kasance sesamol kadai, wani don shan magani na yau da kullun na glibenclamide (Glyburide), kuma na ƙarshe ga duka sesamol da Glyburide na kimanin makonni 7.

An bayar da rahoton cewa Sesamol yana da tasirin aiki tare tare da glyburide, saboda maganin haɗin gwiwa ya saukar da haemoglobin A1c da matakan sikarin jini ƙwarai da gaske, kuma ya fi kyau fiye da ɗayan hanyoyin maganin guda ɗaya.

Hyperlipidemia. Masu binciken sun bayar da rahoton cewa sinadarin sesamol da ake amfani da shi wajen kona cholesterol da sauran kayan shafawa a cikin jini ya bayar da sakamako mai kyau. A cikin gwajin samfurin, an gwada tasirin sesamol akan cin abinci mai ƙiba mai haɗari-haɗarin hyperlipidemia, cututtukan jini na yau da kullun, hypercholesterolemia, da m hyperlipidemia.

Rage matakan triacylglycerol kamar yadda sakamakon ƙarshe ya nuna cewa sesamol yana rage tasirin triacylglycerol. Hakanan ana amfani da Sesamol don juya matakan cholesterol da aka haɓaka.

Nazarin ya bada shawarar cewa karin sinadarin sesamol yana kara fitar da cholesterol gami da rage shan shi.

 

VI. Ciwon rashin lafiya da kiba.

An bayar da rahoton Sesamol yana ƙunshe da iyawar ilimin ɗan adam da dama gami da ikon dawo da kiba da rikicewar rayuwa. An bayar da rahoton cewa zai iya hana tasirin kiba.

Binciken da aka gudanar don gwada yadda tasirin sinadarin sesamol yake game da kiba, an gano cewa zai iya daidaita maganin kumburin ciki na hanta. Wannan ya inganta haɓakar insulin daga baya kuma ya haɓaka asarar nauyi. Kiba da cututtukan cututtukan da ke tattare da ita suna da alaƙa da haɗuwar lipid cikin jiki. Rage tarin kaya yana nufin juyawar yanayin kiba.

Sesamol amfani yana ƙaruwa lipolysis, magarya mai ƙoshin mai da rage ƙwanƙwan hanta na hanta, abubuwa masu mahimmanci wajen rage haɗuwar lipid. Waɗannan ayyukan (watau ɗaukar lipid, haɗuwa da haɗari) suna cikin yawancin da ke faruwa a cikin hanta.

Mutanen da ke amfani da sesamol sun ba da rahoton mafi kyawun bayanan hanta da kwayar cuta, kuma sun inganta ƙwarewar insulin.

 

vii. Rheumatoid amosanin gabbai, Osteoarthritis, da osteoporosis.

Kodayake cututtukan zuciya na rheumatoid, cuta mai raɗaɗi da ci gaba, yana da hanyoyin kwantar da sinadarai da yawa, yawan amfani da su na tsawon lokaci yawanci hepatotoxic. Sesamol na iya zama maganin halitta na yau da kullun. Nazarin da ke bincike iri daya ya ba da rahoton cewa sesamol yana da mafi ingancin maganin cututtukan zuciya da cututtukan kumburi wanda ke inganta tasirin cututtukan zuciya na rheumatoid.

Osteoarthritis shine babban abin da ke ba da gudummawa ga ciwon haɗin gwiwa, wanda aka kiyasta zai shafi kusan 15% na yawan mutanen duniya. Matsanancin kuzari, duk da haka, yana da babban ɓangaren rashin aiki na tsoka. Bincike kan tasirin sesamol akan cututtukan haɗin gwiwa mai alaƙa da osteoarthritis ya nuna cewa shan ƙarin sinadarin na tsawon mako zai iya rage zafi. Wannan an danganta shi ne ga dukiyar sesamol mai danniyar-oxidative.

Masana kimiyya sun yanke shawara cewa irin wannan tsari zuwa postmenopausal osteoporosis yana gudana don haifar da ovariectomy, inda ake samun ci gaba mai raguwa a nauyin kashi da ƙarfi. Sabili da haka an gano cewa asarar kashi yana da alaƙa da estrogen. An bayar da rahoton Sesamol don ɗaure ga masu karɓar estrogen da kuma haifar da kwafin kwayar halittar-kwayar halitta. Abubuwan amfani masu amfani suna haɓaka ƙarfin ƙashi ta hanyar samar da sunadaran matrix ƙashi.

 

viii. Alzheimer cuta, tashin hankali da bugun jini.

Cutar Alzheimer cuta ce mai ci gaba da lalacewar kwakwalwa dangane da lalacewar ƙwayoyin kwakwalwa. Yana yawan kauda 'yancin tunani na mutanen da abin ya shafa. Abubuwan da ke haifar da kwayar cutar sesamol an ba da rahoto mai alamar rahama. An saita binciken don haɓaka ƙarfin sesamol na warkewa a cikin farfadiya, yanayin da ke da alaƙa da rashin hankali da ƙarancin azanci. Binciken ya kammala cewa sesamol yana haifar da sakamako mai kyau akan bugun jini, rashin lahani, kamuwa, da damuwa na gajiya. Amfani da Sesamol don maganin antiepileptic na iya zama da amfani.

 

Amfanin Sesamol

[a]. Sesamol Anti-oxidant effects

Stresswayar damuwa yana faruwa lokacin da rashin daidaituwa a cikin samar da kwayoyi masu raɗaɗɗa da antioxidants a cikin jiki. Wannan yakan haifar da lalacewar kwayar halitta da damuwa na oxyidative a matsayin tushen asalin rikice-rikice da yawa.

Stresswayar motsa jiki shine tsarin ilimin lissafi wanda yake haifar da tsufa.

Antioxidants a gefe guda abubuwa ne waɗanda ke hana lalacewar ƙwayoyin saboda ƙwayoyin cuta masu kyauta. Sau da yawa ana kiran su masu raɗa raɗaɗɗen rashi.

Sesamol shine mafi mahimmancin ƙarfi da ƙarfin antioxidant na man sesame. Yana aiki ta hanyoyi daban-daban don sadar da tasirin antioxidant. Wadannan hanyoyin aikin sun hada da kayyade tsari na mahimman ayyukan antioxidant, kariya ta DNA daga lalacewar radiation, sassaucin radicals free, hana lipid peroxidation, da kariya daga ultraviolet radiation.

Nazarin binciken kimar kwayar halitta ta sesamol akan yaduwar cutar gamma a cikin DNA. Lalacewar DNA ta haifar ne ta hanyar gabatar da hutu iri ɗaya ko sau biyu ta hanyar ƙarni mai aiki da nau'in oxygen.

Sesamol an samo shi don hana haɓakar DNA guda ɗaya. Hakanan ya rage matakan masu tsattsauran ra'ayi musamman na hydroxyl, DPPH, da ABTS masu tsattsauran ra'ayi, waɗanda duk suna da alaƙa da gabatarwar guda ɗaya ko biyu.

 

[b] Sesamol Anti-mai kumburi amfanin

Kumburi tsari ne na dabi'ar halitta wanda jiki ke amfani dashi don yaƙar wakilan baƙi kamar ƙwayoyin cuta, fungi, ko ma rauni. Koyaya, ciwon kumburi na yau da kullun yana da lahani ga jiki saboda yana haifar da matsaloli daban-daban.

Magungunan anti-inflammatory suna taimakawa kare jiki daga lalacewa ta hanyar yaƙi da kumburi. Sesamol yana aiki ta hanyoyi daban-daban don bayar da sakamako mai saurin kumburi. Waɗannan hanyoyin aiwatarwa sun haɗa da hana ƙwayoyin ƙwayoyin cuta, rage samar da nitrites gami da hana aiki da hanyoyin kumburi.

A cikin nazarin beraye tare da cutar sankara mai dauke da lipopolysaccharide LPS, an gano sesamol don murkushe cytokines masu saurin kumburi tare da hana samar da sinadarin nitric da prostaglandin E2 (PGE2). Sesamol an kuma samo shi don tsara adinosine monophosphate-activated protein kinase (AMPK) kunnawa. Wannan yana taimakawa danne kumburi kuma yana rage lalacewar kwayar halitta.

[c]. Sesamol anti ciwon daji effects

Sesamol yana da kaddarorin da ke taimakawa wajen yakar kwayoyin cutar kansa ciki har da ayyukan hana yaduwar kwayoyin cuta ta hanyoyi daban-daban kamar hana karfin membrane, kame ci gaban kwaya a matakai daban-daban da kuma haifar da apoptosis.

A cikin binciken da ya shafi layin kwayar cutar kanjamau ta DLD-1, an yi amfani da sesamol a kashi 12.5-100 μM. An gano cewa aikin rubutu na COX-2 ya ragu da kashi 50%.

A wani binciken kuma, an gano sesamol da aka yi amfani da shi a babban sashi na 0.5-10 mM don haifar da apoptosis a cikin HCT116 ta hanyar haɓaka oxygen mai ciki (O2 • -) a cikin yanayin dogaro da kashi. Wannan ya haifar da kunna hanyar siginar JNK wanda ke ƙarfafa lalacewar mitochondrial. Wannan kuma yana haifar da fitowar cytochrome c wanda a karshe zai kunna kasusuwan saboda haka haifar da apoptosis.

 

[d]. Seasomol Anti-mutagenic effects

Mutagenicity yana nufin ikon wakili (mutagen) don haifar da maye gurbi. Maye gurbi wanda canji ne a cikin kayan kwayar halitta na iya haifar da lalacewar kwayar halitta kuma ana ɗaukarsa da haifar da wasu cututtuka irin su kansar.

Sesamol an nuna shi yana da ƙwayoyi masu ƙarfi na maganin mutagenic. Amfanin anti-mutagenic ana danganta shi ga aikin antioxidant kuma ƙari don haka ikon iya ragargaza masu rashi kyauta.

A cikin wani binciken, an haifar da mutagenicity ta hanyar samar da iskar oxygen ta hanyar tert-butylhydroperoxide (t-BOOH) ko hydrogen peroxide (H2O2). Sesamol an same shi don yin tasirin anti-mutagenic mai karfi a cikin gwajin Ames na gwajin TA100 da TA102. An san nau'in TA102 mai matukar damuwa da nau'in oxygen mai tasiri. Sesamol shima an nuna shi don hana mutagenicity na sodium azide (Na-azide) a cikin nau'in gwajin mai gwajin TA100.

 

[e]. Sesamol kariya daga radiation

Radiation yana nufin makamashin da ke tafiya cikin sifar taguwar ruwa ko ƙura. Radiation na iya faruwa sosai a cikin yanayin mu. Koyaya, ionizing radiation na iya zama cutarwa idan aka bar shi ba tare da kulawa ba. Exposurearancin ɗaukar hoto zuwa radiation zai iya haifar da cututtukan gaggawa kamar su cutar radiation da kunar rana a jiki.

Fadada kamuwa da cutar ta radiation yana haifar da mummunar cuta ciki har da cutar kansa da cututtukan zuciya.

A cikin nazarin beraye tare da lalatawar lalacewar DNA, sesamol an kimanta shi don aikin kare shi daga radiation. Yin maganin beraye tare da sesamol ya haifar da kariya daga lalacewar DNA.

 

[f]. Kariyar zuciya

An bayar da rahoton Sesamol don bayar da kariya ga bugun zuciya daga rauni.

A cikin binciken don kimanta kariyar sesamol game da cutar ta myocardial, an gudanar da shirin sesamol a (50 mg / kg) na kwanaki 7 kafin lokacin aikin.

Wannan binciken ya gano cewa sesamol ya rage girman infarct, ya yi amfani da alamomin zuciya, ya hana sinadarin lipid peroxidation, shigar kwaroron ciki tare da daga matakin antioxidants. , kuma ya inganta aikin furotin na Bcl-3 na anti-apoptotic.

 

[g]. Sesamol Free masu tsattsauran ra'ayi

Free radicals sune m atoms wadanda suke samun electron daga wasu kwayoyin halitta cikin sauki. Dukansu suna da amfani kuma suna da guba gwargwadon natsuwarsu. A ƙananan matakan 'yan raji masu kyauta suna taka rawa a cikin martani na rigakafi, kodayake, lokacin da hankalinsu ya yi yawa sai su zama masu cutarwa. Abubuwan da ke da 'yanci na yau da kullun suna haɓaka haɓakar ƙwayar cuta wanda zai iya lalata ƙwayoyin cuta kuma yana iya haifar da mafi yawan ci gaba da rikicewar cututtuka irin su ciwon daji, cututtukan zuciya, da amosanin gabbai, ciwon ido, da cututtukan neurodegenerative.

Jikinmu yana magance tasirin damuwa na gajiya ta hanyar samar da antioxidants duk da haka baza su isa ba kuma suna buƙatar kari ta abinci ko kari.

Sesamol yana da 'ikon hana samuwar samuwar' yanci kyauta kuma yana iya ragargaza masu radar.

A cikin wani binciken da ya shafi kwayar halittar fatar jikin dan adam da ake kira fibroblast (HDFa) wacce aka fallasa ta UVB, an kimanta shirin samar da sinadarin sesamol ne game da sinadarin cytotoxicity, sinadarin oxygen mai saurin shiga ciki (ROS), maganin peroxidation na lipid, yanayin antioxidant, da kuma lalata sinadarin DNA. Sesamol an samo shi don rage yawan peroxidation na lipid, cytotoxicity, ROS intracellular, da lalata DNA a cikin ƙwayoyin fata na mutum. An danganta wannan ga ikon ƙarin sesamol don kawar da ROS.

Irin wannan binciken ya ba da rahoton haɓaka aikin enzymatic da ba enzymatic wanda ke ba da gudummawa ga mafi kyawun aikin antioxidant.

 

[h]. Yana rage cholesterol na jini

Cholesterol na jini abu ne mai kama da kitse a jikinku. Jiki yana buƙata don gina ƙwayoyin lafiya amma cikin adadin da ya dace. Ana jigilar cholesterol a kan nau'ikan nau'ikan nau'ikan kwayoyi biyu, masu ƙarancin ƙarfi, da kuma masu ƙarfi. Ta haka ne yake kawo nau'ikan nau'ikan cholesterol guda biyu, cholesterol mai saurin-lipoprotein (LDL), da cholesterol mai ƙarfi mai ƙarfi (HDL).

LDL galibi ana kiranta azaman mummunan cholesterol tun daga matakan LDL da yawa kara kasadar kamuwa da cututtukan jijiyoyin jini da sauran cututtuka.

Sesamol na iya rage matakin cholesterol da kuma matakin triacylglycerol a cikin jiki.

A cikin gwajin haƙuri na mai, sesamol (100 da 200 mg / kg) an sami mahimmanci (P <0.05) rage shayar triacylglycerol don haka saukar da matakin triacylglycerol a cikin jiki. Triacylglycerol shine babban ɓangaren mai da aka adana a cikin ƙwayar adipose.

A cikin nazarin berayen zabiya na Switzerland tare da cutar hyperlipidemia, an bayar da rahoton ƙarin sesamol a 50 da 100 mg / kg don rage matakan duka cholesterol da triacylglycerol sosai.

Ayyukan sesamol na rage yawan cholesterol da matakan triacylglycerol ana danganta shi da ikonsa na rage sha da kuma kara fitar da kodin.

 

[i] Sesamol na amfani da fata

Fatar jikin mutum wani ɓangare ne na tsarin haɗin gwiwa wanda aikin sa na farko shine bayar da kariya ga gabobin jiki.

Sesamol yana amfani da fata ta hanyoyi daban-daban saboda halayenta masu ƙarfi ciki har da antioxidant, da aikin anti-inflammatory. Sesamol yana amfani da fata ta hanyar

 

· Kare fata daga hasken ultraviolet (UV)

Doguwar fallasa zuwa hasken rana na iya haifar da haɓakar haɓakar haɓakar haɓakar oxygen (ROS), wanda zai iya haifar da lahani na fata kamar lalacewar collagen a cikin fata da hyperplasia na epidermis

Sesamol na da ikon yin amfani da shi don kawar da cututtukan da ke faruwa sakamakon dadewa a cikin hasken rana don haka kare fata daga lalacewar DNA. Yana bayar da kariya mai kariya wacce ke taimakawa hana hasken fata lalacewar hasken UV.

Bincike ya bayar da rahoton cewa sesamol na iya rage karfin cytotoxicity da ke haifar da UVB. Hakanan an bayar da rahoton don hana ƙwayar melanin biosynthesis ta hanyar rage bayanin tyrosinase, MITF, TRP-1, TRP-2, da MC1R a cikin ƙwayoyin melanin.

Wani binciken ya gano cewa sesamol na iya hana kira na melanin ta hanyar tasiri CAMP / protein kinase A (cAMP / PKA), protein kinase B (AKT) / glycogen synthase kinase 3 beta (GSK3β) / CREB, TRP-1, da MITF a cikin B16F10 sel

 

· Taimaka a kula da fata mai sheki

Sesamol sananne ne mai ƙarfi antioxidant. Yana zurfafa cikin fata don haka yana ciyar da fata. Wannan kuma yana taimakawa samun fata mai haske.

 

· Yana kawar da fata

Acne wani yanayi ne wanda ke toshe kofofin fata da mai, datti, da wasu kananan kwayoyin cuta.

Sesamol ya mallaki kayan antibacterial wanda ke ba shi damar kawar da ƙananan ƙwayoyin cuta don haka samun fata mara kyau daga kuraje.

 

· Yana ba da sakamako mai tsufa

Tsufa tsari ne na rayuwa tsaka-tsaki. Koyaya tsufa da wuri zai iya faruwa saboda dalilai da yawa irin su dogon haske ga haskoki na UV, damuwa mai raɗaɗi tsakanin wasu.

Sesamol yana ba da aikin antioxidant mai ƙarfi wanda ke hana fata da jiki daga haɓakar salula da haɓaka fatar jiki.

An kuma bayar da rahoton Sesamol don hana faruwar layuka, pores, da wrinkles.

 

[j]. Amfanin Sesamol ga gashi

Aikace-aikace na man sesame yana ciyar da fatar kan mutum, gashin gashin kansa, da kuma sandunan ruwa. Wannan yana inganta ci gaban gashi lafiya. Hakanan yana taimakawa wajen warkar da duk wani lahani da aka lalata ta hanyar sinadarai yayin gyaran gashi ko rini.

Rashin tsufa da wuri na gashi na iya faruwa saboda raguwar ƙarfin jiki don yin isasshen melanin, da kuma wasu dalilai irin su damuwa mai raɗaɗi, salon canjin halittar gado tare da abinci da kuma amfani da magani.

Arin Sesamol ya tabbatar da cewa yana iya kula da launin gashi da kuma sanya baƙin gashi mai launin toka.

Bayan haka, sesamol na iya taimakawa wajen kawar da dandruff. Dandruff na iya faruwa saboda bushewar fata, halayen rashin lafiyan kayan gashi, da haɓakar naman gwari akan fatar kan wasu abubuwa. Sesamol yana taimakawa ciyawar fata don haka kula da lafiyayyen fatar kai don haka ya hana faruwar dandruff. Ayyukan antibacterial kuma suna tabbatar da fatar kan mutum bashi da ƙwayoyin cuta waɗanda ke haifar da dandruff.

 

Hanyoyi guda uku na sesamole

①. Cirewa daga man Sesame

Sesamol kira daga man Sesame shine mafi sauki daga cikin hanyoyin guda uku. Koyaya, yana da tsada sosai. Don haka wannan hanyar ba ta da kyau don samar da masana'antu, musamman saboda tsadar samarwar.

 

②. Kirkirar roba wanda ya samo asali daga piperamine

Kodayake yana da wadatar tattalin arziki ga babban sikelin sesamol, duka hanyar sesamol synthesis daga piperamine yana amfani da ƙananan sikelin samar yayin da ake amfani da aikin samar da ruwa da aiki. A irin wannan yanayin, yiwuwar canza launin sakamakon sakamakon haɗawa da amsawar gefen ba makawa.

 

. Hanyar ta hanyar roba ta samo asali daga jasmonaldehyde

Hanyar Semi-roba wanda ya samo asali daga jasmonaldehyde shine tsarin sesame phenol synthesis wanda aka fi amfani dashi yayin da ake nufin masana'antu. Tsarin ya ƙunshi hadawan abu da iskar shaka da ƙwaƙwalwa kuma saboda wannan, sakamakon sesame phenol yana da inganci da launi mai girma.
A tsari yana amfani da kudin-m oxidant da reactive hakar fasahar, kunna sauri rabuwa da samfurin daga hakar yankin. Wannan yana rage yiwuwar faruwar abin a gaba. Ba abin mamaki ba ne samfurin ƙarshe (kamar farin lu'ulu'u) yana da inganci ƙwarai dangane da launi kuma sesamol yawa.

 

Inda za saya sesamol

Ana samun foda Sesamol akan layi daga daban masana'antun sesamol. Yawancin masu amfani da sesamol suna saya daga daban yanar, wasu don talla ko manufar talla.

Tabbatar da halaccin kowane masana'antar sesamol ta amfani da dokokin jihar da aka zayyana kafin siyan.

 

References

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