Orlistat

Bayanin Buga na Orlistat foda

sunan	Orlistat foda
Bayani	White crystalline foda
CAS	96829-58-2
kima	≥99%
solubility	kusanluble cikin ruwa ko giya, mai narkewa a cikin Acetic acid, etyl ester.
kwayoyin Weight	495.7 g / mol
Marin Matsa	50 ° C
kwayoyin Formula	C9H7ClN2O5
sashi	30mg
Storage na dan lokaci	2-8 ° C Fir daskarewa
Grade	Takardar Pharmaceutical

 

Menene jerin abubuwa?

Orlistat magani ne na likitanci wanda aka nuna don maganin kiba a haɗe tare da rage rage kalori da abinci mai ƙarancin mai. Ana siyar dashi azaman magani wanda aka siyar dashi a karkashin suna mai suna Xenical sannan kuma azaman kantin sayar da magani mai hana kiba karkashin sunan kasuwanci Alli.

Orlistat shine mai hana maganin ciki na ciki wanda yake aiki da farko don hana sha da ƙwayoyin mai. Orlistat shine nau'in saturate na lipstatin, wanda shine ingantaccen mai hana ƙwanƙyasar ƙwayar cuta. Orlistat yana da sauƙi kuma yana da karko don haka aka zaɓi shi akan tsarin mahaifarta na lipstatin.

Orlistat yana aiki don bayar da asarar nauyi mai yawa akan lokaci kuma yana rage ƙwayoyin visceral. Duk da haka ana amfani dashi tare da wasu fasahohin asarar nauyi irin wannan abinci mai ƙarancin mai da motsa jiki. Amfanin sa kamar kowane shirin rage nauyi ba nan take bane amma shiri ne na dogon lokaci, wanda likitocin suka bada shawarar.

Tunda yana aiki ta hanyar toshe shan ƙwayoyin abincin da ke ba su damar canzawa ba tare da canzawa ba a cikin jikin mutum, akwai abubuwan da ke faruwa na ciki da ke faruwa tare da amfani da shi. Wadannan cututtukan na iya canzawa zuwa cikin mawuyacin tasiri da ƙari tare da ƙara sashi. Don cin nasara ko rage lahani ko jerin gwanon ya kamata a ɗauka tare da abinci mara ƙoshin mai kazalika da abubuwan hada magunguna da yawa. 

 

Ta yaya Orlistat ke aiki & Menene Ainihi Yayi?

Orlistat an san shi azaman mai hana mai hana cutar pancreatic da na ciki. Wadannan enzymes (gastric and pancreatic lipases) suna da alhakin raunin triglycerides (mai / kitse a jiki) a cikin hanji.

Orlistat yafi nuna tasirinsa a cikin lumen ciki da kuma cikin ƙananan hanji. Orlistat sananne ne don ɗaure ga ragowar sashin yanar gizo na maganin ciki da na lipase don samar da haɗin gwiwa. Wadannan enzymes saboda haka an kashe su kuma basu da isashshi ga mai cin abincin hydrolyze a cikin nau'ikan triglycerides cikin acid mai da kuma monogylcerides wanda jiki zai iya sauƙaƙe cikin sauƙi.

Lokacin da aka hana ayyukansu, triglycerides da aka samo daga abincin ɗan adam ba a canza su zuwa ƙwayoyin mai waɗanda jiki zai iya sha. Sabili da haka, triglycerides ana cire su babu canzawa a cikin najin mutum. Tunda ba'a canza triglycerides ba a cikin jiki, wannan yana haifar da rashi na caloric wanda ke taka rawa wajen kula da nauyi.

Kwanan nan, an kuma sami jerin sunayen a matsayin mai hanawa yankin thioesterase na fatty acid synthase (FAS). Enzyme, thioesterase, yana da alaƙa da yaduwar ƙwayoyin cuta amma ba a cikin haɓakar ƙwayoyin halitta ba.

 

Shin jerin ayyuka suna aiki idan baku cin mai?

Da kyau, jerin suna aiki don rage adadin kitsen da ke cikin tsarin jiki. Sabili da haka babu buƙatar ɗaukar jaka yayin cin abinci ba tare da mai ba. Idan kuna cikin jerin magunguna kuma kuna cin abinci ba tare da mai ba, an shawarce ku da ku tsallake kashi don kauce wa haɗarin haɗarin.

Koyaya, idan kun ci abincin da yake da ƙoshin mai, kuna iya fuskantar shi ko jerin abubuwan illa kamar kujerun mai, gas na hanji da tabo mai.

 

Orlistat ya tabbatar da rage mai visceral?

Haka ne, hakika an tabbatar da jerin sunayen asibiti don rage kitsen ciki. Alli (orlistat 60 MG) an yarda da shi ta Hukumar Abinci da Magunguna (FDA) a matsayin magani na kan-kanti don magance kiba.

Nazarin asibiti ya tabbatar da hakan kolistat ba wai kawai yana taimakawa ga asarar nauyi ba amma kuma yana rage ƙwayoyin visceral sosai. An gano ya rage kewayen kugu.

Kitsen visceral wanda ake kira mai aiki shine nau'in mai mai hatsari wanda aka adana a cikin ramin ciki saboda haka yana kewaye da mafi girman gabobin ciki kamar hanta, hanji da kuma pancreas. Yawancin kitsen visceral suna da nasaba da matsalolin lafiya da yawa kamar su ciwon sukari na 2, cututtukan zuciya, wasu cututtukan kansa, hauhawar jini, da cutar Alzheimer.

Yayin rage nauyi, kitse na visceral yana daga cikin kitse na farko da za a rasa. Wannan yana inganta lafiyar ku ta hanyar rage haɗarin mafi yawan matsalolin kiwon lafiya kamar su ciwon sukari, hauhawar jini, da cututtukan zuciya.

A cikin binciken da ya kunshi mahalarta 26, an gudanar da jerin sunayen 60 mg (Alli) sau uku a rana a hade tare da rage kalori, rage cin abinci mara nauyi na tsawon watanni 3. Sakamakon ya nuna cewa, jerin sunayen sun iya rage kewayen kugu wanda shine ma'aunin kitse na visceral. Sun bayar da rahoton rage kashi 5.6% cikin nauyin jiki da 10.6% raguwa a cikin kitse na visceral.

A wani binciken kuma, an ba mutane 123 masu kiba sau uku a kowace rana don makonni 24. An kuma shawarce su da su kiyaye abinci mara nauyi. Bayan wata na shida, mahalarta sun ba da rahoton raguwar nauyin jiki na 5.96% da raguwar ma'anar kitsen visceral na 15.66%.

 

Shin jerin sunayen suna haifar da lalacewar hanta?

Ba a gano Orlistat a matsayin ainihin abin da ke haifar da mummunan hanta mai haɗari a cikin gwajin asibiti da na asibiti. Koyaya, wasu al'amuran da ba safai ba waɗanda suka kamu da cutar hanta mai haɗari sun ruwaito su ta mutanen da suka yi amfani da jerin sunayen.

Orlistat na iyakance aikin enzyme mai mahimmanci wanda ake kira carboxylesterase-2. Enzyme, carboxyleserase-2 na taka muhimmiyar rawa wajen lalata gurɓata hanta, ƙoda da kuma dukkanin sassan yankuna na ciki. Lokacin da aka hana wannan enzyme din to yana iya haifar da mummunan lahani ga gabobi masu mahimmanci. 

Saboda haka Hukumar Abinci da Magunguna ta sanya mummunan rauni na hanta azaman damuwa game da aminci dangane da jerin sunayen. Wannan ya dogara ne da kimanin abubuwa 13 na lalacewar hanta bayan kasuwa bayan amfani da jerin sunayen.

A cikin karatun da aka gudanar, ba a gano jerin abubuwan da ke haifar da mummunar cutar hanta ba. Koyaya, haɗarin haɗarin haɗarin rauni na hanta haɗuwa bai kamata a watsar da shi ba. Yana da kyau koyaushe ka shawarci likitanka don mafi kyawun shawara kafin shan jeri ko kowane magani.

 

Orlistat fa'idodi

Babban mahimmancin fa'idodi shine asarar nauyi. A zahiri, asarar nauyi a cikin tsari shine na farko kuma sanannen fa'ida aka kera shi kuma ake tallatawa. Ana amfani dashi don magance kiba da taimako cikin raunin kiba.

Abubuwan amfani sune:

 

Jiyya kiba

Kiba da kiba suna nufin cuta mai haɗari ko haɗuwa a jiki. Wannan tarin yawa ya mallaki babban haɗarin lafiya. Ma'aunin kiba shine ma'aunin girman jiki yawanci ana lasafta shi azaman nauyinku a cikin kilogram wanda aka raba shi da murabba'in tsayinku a mita.

Kiba tana da alaƙa da matsalolin lafiya kamar cututtukan zuciya, ciwon sukari, wasu cututtukan daji da hawan jini. Abin takaici, koda ƙananan asarar nauyi na iya hana lamuran lafiyar da ke tattare da kiba.

A dabi'ance, yawancin masu kiba da masu kiba suna rasa nauyi ta hanyar duba abinci, salon rayuwa tare da motsa jiki. Magunguna ko magunguna masu asara an tsara su don biye da salon rayuwa mai kyau azaman ƙarin zaɓi.

Rage nauyi, duk da haka, baza'a iya samun nasara dare ɗaya amma yawanci shiri ne na dogon lokaci. Tsarin hasara mai nauyi yawanci zai ƙunshi abinci mai kyau, motsa jiki, da inda magani mai mahimmanci. Tsarin hasara mai nauyi yawanci ana ɗauka mai nasara ne lokacin da ka rasa kashi 5 cikin ɗari ko fiye na nauyin kulawarka na farko a cikin shekara guda. Wannan yana nufin cewa kuna buƙatar rasa kusan rabin kilogram a cikin makon farko na jiyya. Wannan ƙananan asarar nauyi yana tabbatar da cewa ku kiyaye nauyi ko ma rasa ƙarin nauyi tare da ci gaba da shirin rage nauyi.

Orlistat da aka yi amfani da shi tare da rage kalori da rage cin abinci mara nauyi tare da motsa jiki yana ba da shirin rage nauyi mai nauyi. Orlistat, mai hana ciki lipase, zai iya rage adadin abincin da kuke sha ta 25%. Orlistat yana aiki ta hanyar hana lipases na ciki da na pancreatic. Waɗannan su ne enzymes waɗanda ke rarraba mai mai ƙarancin abinci (triglycerides) zuwa cikin sifa mai ƙayatarwa, acid mai ƙanshi ko kuma monocerides.

Lokacin da aka hana ayyukan waɗannan enzymes, jiki ba zai iya ɗaukar adadin kuzari ba amma dai ƙwayoyin sun zama ba su lalace ba a cikin feces. Wannan wani muhimmin al'amari ne wajen kula da nauyi.

An gudanar da bincike na asibiti da yawa kuma sun tabbatar da cewa jerin abubuwan asara masu nauyi suna da ƙarfi.

A cikin binciken da ya kunshi mahalarta 3,305 wadanda suka yi kiba, an gudanar da jerin gwano a MG 120 sau uku kowace rana don shekaru 4. An kuma shawarci mahalarta su ci gaba da cin abincin kalori mara nauyi tare da fiye da 30% na adadin kuzari. An shawarce su da su motsa jiki ta hanyar yin tafiye-tafiye kowace rana.

Wannan binciken ya gano cewa, matsakaicin nauyin da aka rasa a shekarar farko ya kai kilo 10.6. Kodayake mahalarta sun sami nauyi a cikin shekaru uku na gwaji, a ƙarshe, matsakaicin nauyin da aka rasa ya kai kimanin kilo 5.8.

A cikin wani binciken binciken shekara guda da aka gudanar wanda aka samu ya haifar da 5% ko fiye da asarar nauyi.

Sauran fa'idodin jerin sunayen sun hada da;

 

Orlistat Rage haɗarin kamuwa da ciwon sikari na 2

Rubuta ciwon sukari na 2 ko ciwon sukari mellitus mummunan yanayi ne wanda ke tasiri tasirin sukari (glucose) cikin jiki. Yana faruwa ne lokacin da jikinmu bai damu da insulin ba. Insulin shine hormone da ke da alhakin daidaita yawan sugars (glucose) a cikin jiki. Hakanan zai iya faruwa idan pancreas baya samar da isasshen insulin don kiyaye matakan glucose daidai a cikin jiki.

Kodayake ba a san ainihin abubuwan da ke haifar da rashin hankali na insulin ba, kiba yana ɗaya daga cikin abubuwan da ke ba da gudummawa ga ci gaban ciwon sukari na nau'in 2. Rubuta alamun cutar sikari na iya zama da sauƙi a yi watsi da su yayin da suke ci gaba a hankali, duk da haka, idan ba a kula da su ba zai iya haifar da ƙarin rikitarwa. Ci gaba mai ciwon sukari na 2 na iya haifar da ƙarin matsaloli kamar hauhawar jini, cututtukan zuciya da bugun zuciya. Wadannan alamomi da alamomin sun hada da yawan yin fitsari, yawan kishirwa, rage kiba ba da niyya ba, gajiya, rashin gani sosai, yawan kamuwa da cuta, raunuka masu saurin warkewa da kuma duhu a wasu yankuna na fata kamar su wuya da guntun kafa.

Orlistat magani ne mai asarar nauyi mai nauyi saboda haka yana taka muhimmiyar rawa wajen hana farkon fara ciwon sukari na 2. Wasu ayyukan yanayin jerin abubuwan da aka gano don taka rawa a cikin ciwon sukari na 2 sun hada da haɓaka ƙwarewar insulin, rage ƙarancin plasma wanda ba a wadatar da shi ba, rage gudu ko hana narkewar ƙwayoyin mai, rage kitse na ciki, da kuma haifar da ɓoye-kamar peptide-1 kamar glucagon a cikin ƙananan ƙananan hanji.

A cikin wani binciken da aka yi da masu kiba, jerin sunayen da aka samu tare da rayuwa mai kyau (cin abinci mara nauyi da motsa jiki) an gano zai rage yawan kamuwa da ciwon sikari na 2. Hakanan ya haifar da asara mai yawa.

An kuma gudanar da wani binciken tare da masu kiba ko masu kiba da ke fama da ciwon sukari na nau'in 2. Orlistat 120 MG an gudanar sau uku a kowace rana tsawon watanni 6 ko 12.

An gano cewa baya ga orlistat tasirin hasara mai nauyi, orlistat ya sami damar haɓaka glycaemia iko. Sigogin glycaemia da aka inganta sune raguwa a cikin jini plasma glucose (FPG) da haemoglobin A1c (HbA1c). Ingantaccen tsarin glycaemia ya kasance mai zaman kansa ne daga raunin nauyi.

 

Orlistat  Zai iya rage hawan jini

Hawan jini wanda aka fi sani da hauhawar jini yanayin lafiya ne wanda ke faruwa yayin da hawan jininka ya ƙaru zuwa matakan gaske sosai kuma galibi zuwa matakan rashin lafiya. Ruwan jini yana ƙaruwa lokacin da jijiyoyin jikinsa suka zama kunkuntar.

Tsawan lokaci zuwa cutar hawan jini na iya haifar da ƙarin yanayi na yau da kullun wanda ke shafar mahimman gabobi kamar zuciya, koda kowane idanu. Mafi yawan alamun cututtukan hauhawar jini sune ciwon kai, yawan kuka, canje-canje na gani, jiri, ciwon kirji, rashin numfashi har ma da jini a cikin fitsari.

Orlistat wanda ke hana mai liba yana taimakawa wajen hana shan kitse mai ci wanda yawanci zai iya toshe jijiyoyin jini. Orlistat na iya rage ƙananan jini yawanci abin da ke faruwa saboda ƙima.

A cikin binciken da ya kunshi masu kiba 628 ko masu kiba masu fama da hauhawar jini, an ba da jerin gwano a 120 MG sau uku a rana sau ɗaya a shekara. Wadannan marasa lafiya suna da matsin lamba wanda ba shi da iko na matsin lamba na siystolic. Baya ga jerin gwano, marasa lafiya da muka shawarta su kiyaye abinci mai ƙarancin mai don lokacin.

Binciken ya ba da rahoton asarar nauyi mai yawa tare da raguwa a hauhawar jini na diastolic da keɓaɓɓe. Sun rubuta raguwar -9.4 mmHg a hauhawar jini da rage -7.7 mmHg a cikin matsi na diastolic.

Wannan yana nuna cewa za'a iya amfani da jerin gwano wajen gudanar da hauhawar jini a cikin masu kiba ko masu kiba.

Wannan ɗan ragin hawan jini yana da alaƙa da amfani da jerin gwano na dogon lokaci tare da abinci mai ƙarancin kalori da motsa jiki.

A wani binciken kuma, an sami amfani da tsarin amfani da jerin gwano dan rage hawan jini ta hanyar rage raguwa na 2.5 mmHg na systolic da 1.9 mmHg na karfin jini. 

 

Orlistat  Rage duka da LDL cholesterol

Choarancin cholesterol mai ƙananan-lipoprotein (LDL cholesterol) yawanci ana kiransa mummunan cholesterol tunda ya taru a bangon jijiyoyin jini don haka yana ƙara haɗarin matsalolin lafiyarku kamar cututtukan zuciya da bugun jini.

Adadin cholesterol ya kunshi duka mai karamin nauyi (LDL) da kuma kwayar cholesterol mai karfin gaske (HDL). Matsakaicin matakin duka cholesterol ya fi haɗarin rikicewar zuciya.

An bayar da rahoton Orlistat don rage LDL cholesterol ban da fa'idojin asararsa.

A cikin binciken da ya kunshi masu kiba ko masu kiba, an ba da jerin gwano a kashi 120 na MG sau uku kowace rana don makonni 24. Marasa lafiya suna da BMI (nauyin jikin mutum) na 27-40 kg / m2 da hypercholesterolemia (ƙananan cholesterol, LDL-C, 4.1-6.7 mol / l).

An samo Orlistat don rage nauyi da jimla da LDL cholesterol. An ci gaba da nuna cewa tasirin rage tasirin cholesterol na LDL ya kasance mai cin gashin kansa ne daga fa'idodin asarar nauyi. A cikin wannan binciken ko jerin sunayen an sami juriya mai kyau baya ga yawan abubuwan da ke faruwa a cikin ciki.

A wani binciken kuma, an ba wa mutane 448 da ke da babban matakin cholesterol a jerin sunaye a cikin 120 MG sau uku kowace rana na kimanin watanni 6. An kuma umurci marasa lafiyar da su dage da rage kalori da kuma rage cin abinci. Wannan ya haifar da asarar nauyi mai mahimmanci tare da asarar nauyi na kusan kilogram 7.4. Hakanan, an sami raguwa mai yawa a cikin duka cholesterol da ƙananan ƙwayar cholesterol ta 25-30 mg / dL.

Sun kuma bayyana cewa tasirin tasirin cholesterol ya kasance mai cin gashin kansa ne daga jerin sunayen auna asara sakamako.

 

Abubuwan hulɗa na Orlistat

Maganganun ƙwayoyi yana nufin yadda magunguna daban-daban suke da alaƙa ko tasirin wasu. Waɗannan mu'amala da ƙwayoyi suna tasiri kan yadda wasu magungunan ke aiki kuma yana iya ƙara yawan tasirin cututtukan da ke tattare da amfani da wani magani. Orlistat hulɗa tare da wasu magunguna an gano.

Baya ga ma'amala da wasu magunguna, ba a ba da shawarar yin amfani da jerin sunayen ta masu ciki ko masu shayarwa ba. Hakanan ba don amfani da yara yan ƙasa da shekaru 12 ba.

Abu ne mai matukar kyau a kiyaye jerin magunguna ko magunguna kuma a koyaushe a bayyana wa mai ba ku kiwon lafiya don kyakkyawar shawara kan yiwuwar hulɗa. Waɗannan hulɗar da jerin sunayen magungunan ƙwayoyi na iya zama mafi lahani ga lafiyar ku fiye da fa'idodin da aka ɗauka. Sabili da haka, kada ku yi watsi da waɗannan hulɗar amma ku kiyaye.

Wasu sanannun ma'amala tsakanin mutane sune;

 

Orlistat hulɗa tare da masu rage jini

Magungunan jini sune magunguna waɗanda ake amfani dasu don magance wasu cututtukan zuciya da yanayin da zai sanya ku cikin haɗarin haɗarin jini mai haɗari. Galibi suna taimakawa jini ya gudana cikin nutsuwa a cikin jijiyoyin jini. Hakanan yana hana daskarewa daga kafa ko girma.

Wadannan masu yankan jini sun hada da warfarin, heparin, apixaban, dabigatran da rivaroxaban da sauransu.

Orlistat na iya rage shayar bitamin K. Vitamin K rukuni ne na mahadi watau Vitamin k1 da bitamin K2. Vitamin K yana taka muhimmiyar rawa wajen taimakawa jini ya daskare sannan kuma yana hana zubar jini mai yawa. Lokacin da shaye shayensa ya kasance mai iyaka, zaku zama da jini da sauki. Wannan shine dalilin da yasa shan masu sikanin jini tare da jerin gwano yana kara damar samun zubda jini sosai kuma yana iya sanya jini cikin sauki.

Wasu kiwon lafiya zasu ba ku shawara ku daidaita sashin ku na masu rage jini don ku sami damar amfani da su tare da jerin gwano. Koyaya, sai dai idan an ba da shawarar ba za a canza magungunan ƙwayoyi ba.

 

Orlistat hulɗa tare da magungunan HIV

Wadannan kuma ana kiransu magungunan rigakafin cutar. Ana amfani da magungunan rigakafin cutar ne ga mutanen da ke fama da cutar ƙanjamau (HIV) marasa lafiya don rage nauyin kwayar cutar saboda haka ƙara ƙimar rayuwa a cikin marasa lafiya.

Magungunan sun hada da lopinavir, ritonavir, atazanavir, efavirenz, tenofovir da emticitabine.

Lokacin da aka ɗauki waɗannan magungunan tare da jerin sunayen, an bayar da rahoton cewa maganin rigakafin ƙwayar cuta yana raguwa saboda haka kwayar cutar kwayar cutar ta HIV ta ƙaruwa a maimakon haka. Don haka ya kamata ku guji amfani da jerin sunayen da magungunan rigakafin cuta tare.

Idan akwai buƙatar ɗaukar su tare, ya kamata a kula da nauyin kwayar cutar ta HIV a hankali kuma a daina amfani da jerin sunayen idan aka gano nauyin kwayar yana ƙaruwa.

 

Orlistat hulɗa tare da magunguna masu kamawa

Ana amfani da magungunan kamuwa da cututtukan farfadiya don rage cututtukan kamuwa da cuta / farfadiya. Fat wani muhimmin abu ne a cikin masu cutar farfadiya. Wannan saboda haka yana haifar da karɓar nauyi azaman tasirin tasirin waɗannan kwayoyi. Magungunan kamewa sun hada da lamotrigine.

Orlistat a gefe guda yana rage shayar mai. Lokacin amfani dasu tare da magungunan antiepileptic, an bayar da rahoton jerin gwano don rage shan magungunan.

Wasu labaran sun ruwaito cewa an dauki jerin sunayen tare da magungunan ƙwaƙƙwa yana ƙaruwa da aukuwar kamuwa.

 

Orlistat hulɗa tare da cyclosporine

Cyclosporine wanda ake kira ciclosporin kuma magani ne na rigakafin rigakafin rigakafi. Ana amfani dashi don hana jiki ƙi kayan aiki bayan dasawa.

Idan aka yi amfani dashi tare, jerin sunaye yana rage matakan plasma na cyclosporine. Wannan shi ne saboda jerin sunayen da ke iya yin katsalandan tare da shan waɗannan magungunan.

Wasu ƙwararrun likitocin likita sun ba da shawarar kada su yi amfani da jerin abubuwa yayin amfani da cyclosporine. Koyaya, wasu likitocin sun bada shawarar shan cyclosporine kimanin awa 3 bayan shan jerin gwano.

 

Orlistat hulɗa tare da amiodarone

Wannan yana nufin maganin anti-arrhythmic da aka yi amfani da shi don dawo da bugun zuciya na yau da kullun tare da kiyaye tsayayyen yanayi na yau da kullun.

An nuna Orlistat don lalata shayar amiodarone a cikin jini. wannan hanawa yana haifar da mummunan bugun zuciya wanda ke da haɗari ga lafiya.

 

Orlistat hulɗa tare da levothyroxine

Levothyroxine magani ne da ake amfani dashi don magance ƙananan aikin ka kuma yana kula da wasu nau'ikan goiters. Ana kiran ƙarancin aikin thyroid kamar hypothyroidism kuma ya haɗa da alamun bayyanar cututtuka kamar Gajiya, bushewar fata, rashin ƙwaƙwalwar ajiya, riba mai nauyi, kumburi, raunin tsoka, ƙwanjin ƙwayar cholesterol na jini, mafi nauyi fiye da al'ada ko lokacin al'ada, rashin saurin bugawar zuciya, damuwa da goiters .

An bayar da rahoton haɗin gwiwa na levothyroxine da orlistat don rage matakin levothyroxine da ake sha. An bayar da rahoton Orlistat don ɗaure zuwa levothyroxine don haka, tare da hana shan shi a cikin hanjin. Wadannan na iya haifar da mummunan hypothyroidism wanda zai iya haifar da matsalolin lafiya kamar rashin haihuwa, kiba, zafi, da rikicewar zuciya. 

 

Orlistat hulɗa tare da bitamin mai narkewa

Orlistat na iya hana shan wasu bitamin mai narkewa da wasu abubuwan gina jiki. Sinadaran bitamin masu narkewa sun hada da bitamin A, D, E, K da beta-carotene.

Yana da kyau mutum ya sha sinadarin bitamin mai dauke da sinadarai masu narkewa. Ya kamata a dauki ƙarin magani na multivitamin aƙalla awanni 2 kafin ko bayan shan jerin gwano.

 

Orlistat Sakamakon sakamako

Abubuwan lalacewa na yau da kullun na yau da kullun suna faruwa ne saboda ƙwayoyin da ba a lalata su ba ta hanyar tsarin narkewar ku. Yawancin su sune cututtukan ciki tun lokacin da hanyar farko ta jerin sunayen shine na baka kuma ƙwayoyin da basu canzawa suna fita ta cikin feces.

Abubuwan da ke faruwa a jerin sunayen suna faruwa a farkon makonnin farko na shan shi kuma yana iya tafiya. Koyaya, wasu alamun cutar na iya ci gaba. Hanyoyi masu illa na iya faruwa sau da yawa idan sashi ba daidai bane.

Wadannan illolin na iya riskar su ta hanyar shan takardar da ta dace yayin bin shawarar likitanka akan kiyaye rage kalori, rage cin mai mai kaima da motsa jiki.

Abubuwan da aka ba da shawarar orlistat sashi ana ɗaukar MG 120 sau uku a kowace rana. Orlistat ya fi dacewa a sha kafin cin abinci kamar yadda yawanci yakan hana kusan 30% na mai cin abinci daga shayewa. Doididdigar allurai mafi girma ba ta haifar da sakamako mai tasiri ba amma hakan na iya haifar da wasu cutarwa.

Wadannan abubuwan tasirin sun hada da;

• Gaggawa ko wahalar sarrafa motsi
• Sakin jiki da yawaitar hanji
• Daskararre ko mai matse mai
• Ciwon ciki ko dubura ko ma rashin jin daɗin ciki
• Wucewar gas sau da yawa tare da fitarwa mai maiko.

Abubuwan da ke faruwa a sama suna iya zama mafi muni idan kun ɗauki ƙiba fiye da yadda ya kamata ku sha yayin shan magunguna.

Wasu sunaye abubuwa masu illa kodayake ba safai zasu iya faruwa ba. An shawarce ku da ku nemi taimakon likita nan da nan lokacin da kuka lura da waɗannan tasirin. Wadannan jerin abubuwan tasirin suna iya faruwa a cikin maganin miyagun ƙwayoyi. Illolin illa sun hada da;

• ciwon kai
• juyayi
• Tsoma baki a cikin jinin al'ada
• Samun wahalar numfashi
• Difficile haɗiye
• Ciwon ciki mai tsanani wanda ba zai tafi ba
• Tsananin jiri
• Kumburi (galibi a cikin harshe, maƙogwaro ko fuska).

Tunda wasu alamomin da ba kasafai ake samunsu ba na mummunan rauni na hanta an danganta su da yin amfani da jerin sunayen, tabbatar da cewa ka kula da alamun cutar hanta. Ya kamata ku tsaya nan da nan kuma ku nemi taimakon likita idan kun fuskanci waɗannan alamun alamun cutar hanta;

• Wucin lokaci
• Rashin ci
• Hives ko mai tsanani da ci gaba itching
• rauni
• Amai ko jiri
• Jaundice (raunin idanu ko fata)
• Kujerun launuka masu haske / kodadde
• Dark fitsari
• Sauƙaƙe sauƙi
• Kumburi a sawun kafa ko kafa.

Mun lissafa yawancin abubuwan da ke tattare da jerin abubuwan da aka lissafa har ma da masu haɗari da ke tattare da shi, duk da haka, koyaushe ku kasance da sha'awar lura da duk wani tasirin da zaku iya fuskanta kuma kuyi magana da mai ba ku kiwon lafiya. Tabbatar da bin umarni sosai akan sashi da amfani mai kyau na lissafi don daidaita yawancin waɗannan tasirin. 

Kamar yawancin kwayoyi, illolin na iya faruwa a farkon fara magani kuma zasu shuɗe tare da ci gaba da amfani duk da haka, wasu cututtukan na iya ci gaba. Yin maye da yawa shine wani mai ba da gudummawa na yau da kullun ga yawancin tasirin illa, sabili da haka baku ɗauki jerin sunayen fiye da shawarar ba.

 

Inda za saya Orlistat?

Samfurori da ke ƙunshe da jerin suna faruwa a cikin sunayen iri daban-daban. Wannan saboda masana'antun jerin sunayen sun bambanta da natsuwa.

Doseananan kashi na jerin sunayen yana faruwa a cikin jerin sunayen sunayen kamar Alli da Orlos. Ana iya sayan wannan a saukake akan layi daga yawancin masana'antun jerin sunayen da masu samar da jerin sunayen. Koyaya, lokacin da kukayi la'akari da jerin sunayen ku saya shi daga amince likitocin magani. CMOAPI yana ɗaya daga cikin masana'antun jerin sunayen kuma suna ba da samfuran inganci. Da CMOAPI kamfanin sun daɗe suna kasuwancin kuma saboda haka yana ba da tabbaci mai inganci da jerin gwano.

Yi hankali sosai da magungunan kan-kan-counter. Karanta alamun da kyau don fahimtar dacewar amfani da magungunan. Bincika don masana'antar jerin sunayen ko in ba haka ba ko jerin masu kaya, ranar kerawa da ranar karewa. Tabbatar da bincika duk wata illa da aka nuna da gargaɗi. Misali, raunin hanta yana daya daga cikin gargadi ko kuma alama ce ta Hukumar Abinci da Magunguna (FDA) ga masu amfani da su yi taka tsantsan yayin shan magunguna.

 

References

1. "Alamar jerin sunayen Amurka" (PDF). FDA. Agusta 2015. An dawo da 18 Afrilu 2018. Don sabunta lakabi duba shafi na FDA shafi na NDA 020766
2. Barbier P, Schneider F (1987). "Syntheses na tetrahydrolipstatin da cikakken daidaitawar tetrahydrolipstatin da lipstatin". Dokar Helvetica Chimica. 70 (1): 196–202. Doi: 10.1002 / hlca.19870700124.
3. Bodkin J, Humphries E, McLeod M (2003). “Jimlar kira na (-) - tetrahydrolipstatin”. Jaridar Chemistry ta Australiya. 56 (8): 795-803. Doi: 10.1071 / CH03121.
4. Filippatos, Theodosios & Derdemezis, Christos & Gazi, Irene & Nakou, Eleni & Mikhailidis, Dimitri & Elisaf, Moses. (2008). Orlistat-Associated Tasirin Tasirin da Hulɗa da Magunguna. Amincin miyagun ƙwayoyi: mujallar ƙasa da ƙasa game da toxicology da kwarewar magani. 31. 53-65. 10.2165 / 00002018-200831010-00005.
5. Sharma, AM, & Golay, A. (2002). Hanyoyin asarar nauyi a kan bugun jini da bugun zuciya a cikin marasa lafiya masu kiba tare da hauhawar jini. Jaridar hauhawar jini, 20(9), 1873–1878. doi.org/10.1097/00004872-200209000-00034.
6. An yi salo tare da ƙaramin ƙaramin abu a kan marufin, da kuma sandar a kan i (ma'ana, “allī”), amma an ƙara haɓaka ta al'ada a cikin littafin.
7. Zhi J, Melia AT, Eggers H, Joly R, Patel IH (1995). "Bincike game da iyakataccen tsarin shan Orlistat, mai hana maganin lipase, a cikin masu sa kai na lafiya". J Clin Pharmacol. 35 (11): 1103-8. Doi: 10.1002 / j.1552-4604.1995.tb04034.x. PMID 8626884.