Cannabidiol (CBD)

Cannabidiol (CBD) foda Bayanan Basan

sunan	Cannabidiol （CBD）
Appearance	White zuwa haske rawaya crystalline foda
CAS	13956-29-1
kima	≥99% (HPLC)
solubility	Mai narkewa a cikin mai, mai narkewa a cikin ethanol da methanol, mai narkewa cikin ruwa
kwayoyin Weight	314.46
Marin Matsa	62-63 ° C
kwayoyin Formula	C21H30O2
source	Hemp masana'antu
Storage na dan lokaci	Zafin jiki na daki, kiyaye bushe kuma nesa da haske
Grade	Takardar Pharmaceutical

 

Mene ne Cannabidiol (CBD)?

Cannabidiol an san shi da CBD wanda yana ɗaya daga cikin mahaɗan sinadarai sama 100 da aka sani da cannabinoids da aka samo a cikin wiwi ko tsire-tsire, Cannabis sativa. An keɓe shi kuma an tsarkake shi daga ganyen Cannabis sativa, kawai yana ƙunshe da ƙananan THC kaɗan. Tetrahydrocannabinol (THC) da cannabidiol (CBD) suna hulɗa tare da masu karɓa na cannabinoid a cikin jiki duka. Yana da analgesic, anti-mai kumburi, antineoplastic da ayyukan chemopreventive. Bayan gudanar da mulki, cannabidiol (CBD) yana yin aikinsa na yaduwa, anti-angiogenic da pro-apoptotic ta hanyoyi daban-daban, wanda wataƙila ba ya haɗa da sigina ta mai karɓar mai karɓar Cannabinoid 9 (CB1), CB1, ko mai karɓar vanilloid 2. CBD na motsa endoplasmic reticulum (ER) damuwa da hana siginar AKT / mTOR, don haka kunna autophagy da inganta apoptosis. Bugu da ƙari, CBD yana haɓaka ƙarni na nau'in oxygen mai amsawa (ROS), wanda ke ƙara haɓaka apoptosis. Wannan wakili kuma ya tsara maganganun kwayar halitta guda 1 (ICAM-1) da mai hana kyallen takarda na matrixloproteinases-1 (TIMP1) kuma yana rage maganganun mai hana DNA daure 1 (ID-1). Wannan yana hana mamayewar kwayar cutar kansar da metastasis. Har ila yau, CBD na iya kunna mai karɓar mai karɓa mai saurin wucewar nau'in 1 (TRPV2), wanda zai iya ƙara yawan ɗaukar ƙwayoyin cytotoxic a cikin ƙwayoyin kansa. Tasirin analgesic na CBD an sasanta shi ta hanyar ɗaure wannan wakili zuwa kuma kunna CB2. Cannabidiol ana amfani dashi mafi yawa don rikicewar rikicewa (epilepsy) ko ciwo mai laushi da taimako na alamun matsakaici zuwa matsanancin ciwon neuropathic ko wasu yanayi masu zafi, kamar ciwon daji. FDA ta amince da CBD a cikin 1, kuma shine kawai FDA ta yarda da magani ga marasa lafiya da cutar Lennox-Gastaut da cututtukan Dravet.

 

Cannabidiol (CBD) Inji aikin

Ba a fahimci ainihin aikin aikin CBD da THC a halin yanzu ba. Koyaya, sananne ne cewa CBD yana aiki akan masu karɓar Cannabinoid (CB) na tsarin endocannabinoid, waɗanda aka samo su a wurare da yawa na jiki, gami da tsarin jijiyoyin jiki da na tsakiya, gami da kwakwalwa. Tsarin endocannabinoid yana daidaita yawancin martani na ilimin lissafi na jiki gami da ciwo, ƙwaƙwalwa, ci, da yanayi. Mafi mahimmanci, ana iya samun masu karɓar CB1 a cikin hanyoyin ciwo na ƙwaƙwalwa da ƙuƙwalwa inda zasu iya shafar analgesia da ɓacin rai na CBD, kuma masu karɓar CB2 suna da tasiri akan ƙwayoyin rigakafi, inda zasu iya shafar matakan anti-inflammatory na CBD . Cannabidiol (CBD) yana faruwa ne a cikin hanta da hanji. Shan sigarin bioavailability yana da kusan 31%. Rabin rabin rayuwa na CBD bayan feshin oromucosal yana tsakanin awanni 1.4 da 10.9, kwanaki 2 da 5 bayan yawan shan baki, da kuma awanni 31 bayan shan sigari. CBD zai sami matsakaicin ƙimar plasma tsakanin 0 da 4 awanni. An nuna CBD yayi aiki azaman mai maye gurbin mai karɓar mai karɓar CB1 na Cannabinoid, mai karɓar G-Protein Coupled Receptor (GPCR) a cikin jiki. Ana samun daidaitattun allosteric na mai karɓa ta hanyar sauya yanayin aikin mai karɓa a kan wani shafi daban daban wanda yake aiki daga shafin agonist ko antagonist. Hanyoyin da ke tattare da yanayin gyaran maganin na CBD suna da mahimmancin magani kamar yadda masu cin zarafin kai tsaye ke iyakance ta tasirin ilimin halayyar su yayin da masu adawa kai tsaye ke iyakance ta tasirin su.

 

Yadda Ake Amfani da Cannabidiol (CBD)?

Cannabidiol (CBD) shine cirewar wiwi wanda aka kawata don amfanin lafiyarta. Hanyoyi guda biyu da akafi amfani dasu don ɗaukar shi a kasuwa sune maganganu da maganganu ， kamar capsules, tinctures, creams, da ƙari.CBD mai ya kasance mafi shahararren salon aikace-aikacen, hanya ce ingantacciya don ɗaukar cannabinoid. Hadiye digon ruwa da yawa na mai na CBD ya zama hanya mafi sauki kuma ingantacciya don cinye kwayoyin a wannan yanayin. Cannabidiol yana da KYAUTA lafiya yayin ɗauka ta bakin ko fesawa ƙarƙashin harshen yadda ya dace. Cannabidiol a cikin allurai har zuwa 300 MG kowace rana ana ɗauke da baki lafiya har zuwa watanni 6. An ɗauki mafi yawan allurai na 1200-1500 MG kowace rana ta bakin lafiya har zuwa makonni 4. Samfurin cannabidiol na magani (Epidiolex) an yarda da shi don ɗaukar baki cikin allurai har zuwa 25 mg / kg kowace rana. Cannabidiol sprays da ake amfani da su a ƙarƙashin harshe an yi amfani dasu a cikin allurai na 2.5 MG har zuwa makonni 2. Hakanan mutum zai iya ƙara man CBD zuwa abinci da abin sha don rufe dandano. Amma ga waɗanda ke neman taimakawa da guiwa mai ƙarfi ko taƙaita baya, ana iya fifita cream.

 

Cannabidiol (CBD) Amfana

Cannabidiol (CBD a takaice) yana faruwa ne a cikin yanayi Cannabinoid wanda aka samo daga shuka cannabis. Yana ɗayan sama da ɗari cannabinoids da aka gano a cikin tsire-tsire masu tsire-tsire. Koyaya, ba kamar cikakken tsire-tsire na cannabis ba, CBD bai ƙunshi THC wanda ke da alhakin jifan / babban ji da magungunan nishaɗi ke bayarwa ba. An cire shi daga furanni da burodin tsire-tsire, CBD ana matse shi a cikin mai kuma yana da mashahuri don magance, har ma da hana, yawancin batutuwan kiwon lafiya a cikin jihohin inda yanzu aka halatta marijuana na magani. Man na CBD ya fi ƙarfi da ƙari fiye da yawancin ƙwayoyin cututtukan ƙwayoyin cuta marasa ƙarfi (NSAIDs). Dukkanin abubuwa za'a iya fitar dasu kuma inganta su don amfani ta hanyar gajartaccen hanya. Masu amfani zasu iya samun fa'idodin kiwon lafiya masu zuwa:

* Bacci da Tashin hankali

* Ciwon Neurodegenerative

* Sanar da kame-kame

* .Rashin Lafiya da Hankali masu alaƙa

* Ingancin bacci

* Maganin ciwo

* Lafiyar Kashi

* Jaraba & Dogara

* Ci gaban sannu a hankali na cutar Alzheimer

* Yana maganin cututtukan hanji

* .Helps suna ba da taimako ga mutanen da ke fama da cutar ƙwaƙwalwa

 

Cannabidiol (CBD) Tasirin gefen

Illolin cututtukan Cannabidiol (CBD) sun haɗa da bacci, al'amuran ciki, bushe baki, rage ci, tashin zuciya, da hulɗa tare da sauran magunguna.

Cannabidiol (CBD) Aikace-aikace

Cannabidiol ana amfani dashi mafi yawa don rikicewar rikici (epilepsy), Cannabinoid ana haɗuwa tare da tsarin enzyme P450 na cytochrome kuma yana hana yawancin enzymes CYP3A4 da CYP2D6. An gano THC da CBD don hana CYP1A1, 1A2 da 1B1 enzymes yayin nazarin in vitro. Bugu da kari CBD babban mai hanawa ne na CYP2C1P da CYP3A4. Yayinda yawancin gwaje-gwajen asibiti ke gudana, CBD yana nuna ƙwarewa mai ban mamaki don zama ƙarin magani a cikin yanayin yanayin jijiyoyi daban-daban. An samo shi yana da antioxidative, anti-inflammatory, da sakamakon neuroprotective. Ya nuna alƙawari a cikin maganin cututtukan jijiyoyin jiki irin su damuwa, ciwo mai ɗorewa, cututtukan neuralgia, cututtukan Crohn, cututtukan Parkinson da kuma tabin hankali.

Cannabidiol Summary

Cannabidiol yana da wadataccen maganin cannabinoid wanda ake amfani dashi don kula da marasa lafiya da cututtukan farfadiya saboda Lennox-Gastaut ko Dravet syndrome. Cannabidiol yana haɗuwa da haɓakar ƙwayar enzyme mai yawa a yayin farfadowa musamman tare da ƙananan allurai amma ba a haɗa shi da sharuɗɗan cutar hanta ba tare da jaundice.

 

reference

Britch SC, Babalonis S, Walsh SL Canabidiol: ilimin kimiyyar magani da kuma maganin warkewa.Psychopharmacology (Berl). 1 Janairu; 2021 (238): 1-9. Doi: 28 / s10.1007-00213-020-05712. PMID: 8.

2. Samanta D.Cannabidiol: Bincike na Ingancin Ingancin Lafiya da Tsaro a Cutar Farkon Lafiya.Pediatr Neurol. 2019 Jul; 96: 24-29. Doi: 10.1016 / j.pediatrneurol. PMID: 31053391.

3. Huestis MA, Solimini R, Pichini S, Pacifici R, Carlier J, Busardò FP.Cannabidiol Illolin Haɗari da Haɗari. Curr Neuropharmacol. 2019; 17 (10): 974-989. Doi: 10.2174 / 1570159X17666190603171901. PMID: 31161980.

4. Pisanti S, Malfitano AM da dai sauransu Cannabidiol: Yanayin fasaha da sababbin ƙalubale don aikace-aikacen warkewa. Pharmacol Ther. 2017 Jul; 175: 133-150. Doi: 10.1016 / j.pharmthera. PMID: 28232276.

5. Burstein S.Cannabidiol (CBD) da analogs: nazari game da tasirin su akan kumburi.Bioorg Med Chem. 2015 Afrilu 1; 23 (7): 1377-85. Doi: 10.1016 / j.bmc.2015.01.059. PMID: 25703248.

 

Labarai masu amfani