Lorcaserin

CMOAPI yana da cikakken kayan albarkatun mai suna lorcaserin, kuma yana da tsarin gudanarwa mai inganci mai inganci.

Nuna 1-3 na sakamakon 6

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Menene Lorcaserin?

Lorcaserin (Belviq) wakili ne na rigakafin kiba. Idan kun kasance don girgiza ƙarin nauyin jiki ba tare da damuwa game da wasan motsa jiki mai wahala ba, ga abin da ya kamata ku lura kafin sayen magungunan serotonergic.
Lorcaserin hydrochloride ta haɓaka ta Arena Pharmaceuticals. A tsawon shekaru, an yi amfani da shi azaman magani na dogon lokaci don kiba. Supplementarin yana kawar da ci ta hanyar ƙoshewa. Bayan haka, tasirin lorcaserin baya buƙatar ku bi wasu tsauraran matakan abinci ko motsa jiki.
Tun lokacin da aka kirkiro shi, magungunan sun sha gwaji da dama da kuma karatun mutum don tabbatar da inganci da juriya wajen kula da kiba. A cikin 2012, FDA ta amince da lorcaserin (Belviq) don amfani da lafiya amma a ƙarƙashin tsauraran matakai. Misali, an samar da takardar sayan magani ne kawai don manya da masu kiba wadanda ke da alaƙa da cututtukan jiki kamar su hauhawar jini, ciwon sukari, da dyslipidemia.
Akwai sanannun sunaye iri biyu, ma'ana, Belviq da Belviq XR. Dukansu suna kusan kama, suna da lorcaserin hydrochloride a matsayin sashi mai aiki.
Belviq capsules sun ɗanɗan kaɗan, kuma an raba zangon kashi biyu a kowace rana. Contrariwise Belviq XR capsules sun fi girma girma. Wannan sunan mai suna lorcaserin yana da leda mai dauke da leda da za'a dauka sau daya a rana.


Lorcaserin da Lorcaserin Matsakaici

Racemic Chlorocaserin Hydrochloride

Wannan fili ana kiransa da suna lorcaserin hydrochloride. Koyaya, sunan kimiyya shine 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride (CAS: 1431697-94-7).
Racemic Chlorocaserin Hydrochloride foda ya samo asali ne daga hada chlorocaserin hydrochloride dextrorotatory da chlorocaserin hydrochloride. Ana amfani da tsaka-tsakin lorcaserin a cikin nazarin da kuma shirya magani mai nauyi-mai raunin rasa nauyi.

Xtaddamar da Chlorocaserin Hydrochloride

Sinadarin an san shi da suna (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride (CAS no: 846589-98-8). Koyaya, a cikin sharuddan layman, shine (R) lorcaserin hydrochloride.
Wannan matsakaici na lorcaserin shine kayan aikin bincike don nazarin kimiyyar kimiyyar kimiyyar magungunan asara. A cikin karatu na yau da kullun tare da beraye, gidan yana nuna tasirin rashin ƙarfi. Bayan wannan, hakan kuma yana rage yawan amfani da magungunan da ke sanya su kayan maye kamar maganin kafeyin, amfetamine, da magunguna masu alaƙa da su.

Kore Mai Hannun Dama

A kimiyyance, wannan (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzazepine tare da CAS ba. 616202-92-7.
Ana samun koren casserole na hannun dama don dalilai na nazari da dalilai na nazari. Abun yana da damuwa ga masu karɓar 5-HT2C, sabili da haka, yana da amfani a cikin binciken ƙwayoyin cuta masu maye gurɓatuwa.

Dextrorotatory Chlorocaserin Hydrochloride Hemihydrate

In ba haka ba ana kiran wannan mahaɗan kamar lorcaserin hydrochloride hemihydrate. Asalinsa na kimiyya (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride hemihydrate (CAS: 856681-05-5).
Dextrorotatory Chlorocaserin Hydrochloride wani abu ne mai mahimmanci don kira na lorcaserin.

Racemic Chlorocaserin Free Base

Sunan sunanta shine 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzazepine (CAS ba: 616201-80-0).
Racemic Chlorocaserin Free Base samfurin magani ne don amfani dashi wajen bincike da nazarin kimiyya.

Green Card Serin Matsakaici

Sunanta na kimiyya shine 1 - [[2- (4-Chlorophenyl) ethyl] amino] -2-chloropropane hydrochloride (CAS no: 953789-37-2). Green Card Serin kuma matsakaici ne a cikin shirye-shiryen haɓakar lorcaserin.
Ya kamata ku lura cewa duk waɗannan tsaka-tsakin maganganun suna kawai don dalilai na bincike. Abubuwan haɗin ba su dace da amfani da mutum ko dabba ba.


Ta yaya Lorcaserin ke aiki?

Lorcaserin (Belviq) yana ƙaddamar da Tsarin Tsarin Tsarin Hanya ta hanyar yin hulɗa tare da takamaiman masu karɓar hypothalamic. Yana aiki ta kunna serotonin 2C (5-HT2C) akan ƙwayoyin pro-opiomelanocortin. Wannan bangare na kwakwalwa yana da hannu a ci da halaye na abinci. Kodayake akwai wasu ƙananan nau'ikan masu karɓar rago kamar 5-HT2A da 5-HT2B, wannan magani yana da mafi kusancin dangantaka ga 5-HT2C.
Lossarin asarar nauyi na Lorcaserin yana kunna masu karɓar 5-HT2C, sabili da haka, yana haifar da bayyanar alpha-MSH hormones. Alpha-MSH yana aiki ne a kan melanocortin-4-receptors, wanda ke aika sigina zuwa kwakwalwa cewa ka cika.
Abun damuwa na lorcaserin tare da mai karɓar 5-HT2C yana haɓaka ƙoshin lafiya, sabili da haka, rage cin abinci da hanzarta rage nauyi. Dangane da wasu maganganun kimiyya, wannan maganin serotonergic yana daidaita matakan leptin, hormone da ke taka rawa wajen rage nauyi. Plusarin amfani da wannan ƙarin azaman wakili na rigakafin kiba shi ne cewa ba ya haifar da cututtukan zuciya. Dalilin kuwa shine rashin saurin azanci ga masu karɓar 5-HT2B.


Fa'idodin Lorcaserin da Tasirin Gefen

amfanin

Shan lorcaserin hydrochloride yana ƙaruwa da ƙoshin lafiya. Yana taimakawa tare da rikicewar cin abinci, kamar abin da ya saba wa masu ci da sha da yawa. Dangane da gwajin gwaji na lorcaserin, mutum na iya rasa aƙalla 5% na nauyin jikinsu a cikin makonni 12.
Kodayake ba safai ba, rasa kasa da 5% na nauyinka yayin da kake yin lorcaserin yana nufin cewa baza ka taba samun wani sakamako mai ma'ana ba koda kuwa da magani mai tsawo. A wannan gaba, masu bincike sun ba da shawarar cewa ka daina bayar da ƙarin nauyi.
Amfani da wannan wakili na serotonergic babu shakka zai haifar da aikin ƙona mai. Koyaya, yakamata ku haɗa wasu ayyukan motsa jiki yayin da kuke bin abincin mai ƙananan kalori. Bugu da ƙari, tasirin tasiri a cikin gudanar da nauyi ya dogara akan ci gaba da gudanarwa. Tsayar da sashi na iya tasiri tasirin sakamakon.
Bayan gudanar da nauyi, lorcaserin yana aiki ta hanyar fitar da yawan kwayar dopamine sakamakon wasu narcotics kamar maganin kafeyin, morphine, codeine, ko amphetamines. Abubuwan tashin hankali na ƙarin akan masu karɓar maganin serotonin ya sa ya dace da kula da rikicewar hauka.
A cewar masana kimiyya, lorcaserin na iya sauƙaƙa alamun cututtukan schizophrenia tunda yana rage sakin dopamine.

Side Gurbin
  • ciwon kai
  • Dizziness
  • gajiya
  • Tashin zuciya
  • juyayi
  • Ciwo ko ciwon tsoka
  • maƙarƙashiya
  • Yin fitsari mai yawaita da wahala
  • Sleeplessness
  • Dry bakinka
  • Gani ya canza kamar blurriness
  • tari
  • Dry idanu

Fiye da rabi na mummunan alamun cutar na lorcaserin HCl sun kasance saboda yawan abin sama. Kuna iya kewaye da tasirin lalacewar lorcaserin ta hanyar manne wa rigakafin ƙwayoyi. Misali, bai kamata ka wuce zangon sashin yau da kullun ba. Game da yawan abin da ya wuce kima, tabbatar da neman shawarar likita. Wasu daga cikin halayen don dubawa sun haɗa da mafarki, canjin yanayi, ciwon ciki, bugun zuciya mara tsari, da ciwon iska.

Tsanani:

Kafin yin amfani da kariyar lorcaserin HCl, kana bukatar ka yi la’akari da abubuwan da ke gaba na takaitawa da kiyayewar kwayoyi;

  • Wasu masu amfani na iya zama rashin lafiyan abubuwan sinadaran lorcaserin
  • Mata masu ciki da uwaye masu shayarwa bai kamata su ba da lorcaserin ba saboda yana iya shafar jariri
  • Thearin zai iya hulɗa tare da wasu takaddun magani da magungunan marasa magani kuma ya tsoma baki tare da kayan haɗin magunguna
  • Maganin asarar nauyi na Lorcaserin an hana shi ga marasa lafiya masu saukin kamuwa da cutar kansa ko waɗanda suka riga sun kamu da cutar

Wanene Zai Iya Amfani da Lorcaserin?

Lorcaserin yana da amfani a likitanci wajen magance kiba. Dangane da ƙa'idodin FDA, wannan magani na serotonergic ya dace ne kawai da mutane masu kiba tare da BMI na sama da 27kg / m2 da manya masu kiba tare da BMI mafi girma fiye da 30kg / m2. Koyaya, takardar sayan magani tana aiki ne kawai ga marasa lafiya waɗanda ke da larura masu alaƙa kamar dyslipidemia, hawan jini, cututtukan zuciya, da hauhawar jini.
Abokan marasa lafiya ne kawai zasu iya yin sayan lorcaserin don kula da nauyi mai nauyi. Fita cikin gwajin asibiti tare da maganin ya tabbatar fiye da batutuwa na ɗan adam sun kasance sama da shekaru 18. Abin da ya fi haka, ba a tabbatar da amincinsa da ingancinsu a cikin marasa lafiya da ke ƙasa da shekaru 18 ba.
Kodayake kowane babba mai kiba ko babba na iya amfani da kariyar asarar nauyi, akwai wasu rikice-rikice ga indican ƙungiyoyi. Misali, mata masu ciki ba abin tambaya bane. Bayan haka, ba a bayyana ba ko magani ya wuce ta madarar nono, saboda haka, an cire uwaye masu shayarwa daga shan shi.


Menene Bambanci Tsakanin Lorcaserin, Cetilistat, da Orlistat?

Lorcaserin

Lorcaserin HCl shine mai hana ci abinci yayin da jerin gwano da cetilistat suka riƙe hydrolysis na triglycerides cikin acid mai ƙamshi mai narkewa. Arin yana nufin yankin hypothalamic na ƙwaƙwalwar da ke sarrafa ci da ƙoshi. Yin amfani da lorcaserin zai fara jin daɗi kuma ya nuna wa jiki cewa kun cika ba tare da la'akari da ɗan abin da kuka cinye ba. Sabili da haka, asarar nauyi yana farawa saboda rage cin abinci da ƙyamar abinci.
Tare da lorcaserin, mai haƙuri mai ƙiba zai iya rasa sama da 5% na nauyin jikinsu na farko da rage girman kugu na kusan 3cm. Magungunan yana nuna canje-canje masu mahimmanci fiye da lokacin amfani da jerin sunayen.
A cikin 2012, lorcaserin hydrochloride ya sami amincewar FDA kuma ya zama magungunan ƙwayoyi don kiba da cututtukan da suka shafi nauyi. Koyaya, Hukumar Tarayya ta cire shi daga kasuwa saboda karuwar ci gaban cutar kansa tsakanin masu amfani da ita.

Wannanilistat

Kamar dai lorcaserin (Belviq), cetilistat magani ne na hana kiba. Shan magungunan yana toshe kayan lebe, wadanda ke da alhakin lalata triglycerides. A sakamakon haka, triglycerides ba za su iya samar da ruwa a cikin ƙwayoyin mai ba don ingantaccen sha a jiki. Sabili da haka, za a cire ƙwayoyi ba tare da lalacewa ba.
Ceilistat na iya haifar da raguwa har zuwa 10% na nauyin jiki da raguwa mai yawa a kewayen kugu.
Ba kamar sakamako mai illa na lorcaserin ba, mummunan alamun bayyanar cutar ta cetilistat suna da alaƙa da narkewa. Misali, mutum zai fuskanci kwalliya mai yalwa da sako-sako, kumburin ciki, yawan yin hanji, ko rashin karfin ciki.
Ceilistat har yanzu ba ta sami amincewar FDA ba saboda a halin yanzu tana cikin farkon matakan karatun ɗan adam. Ya zuwa yanzu, ƙarin yana da sakamako mai kyau. Kwatantawa tsakanin ƙididdigar asibiti na cetilistat da jerin sunayen sun tabbatar da cewa tsohon yana haɓaka rawan nauyi sosai kuma yana da mafi kyawu.
Thearin cetilistat shi ne cewa ba ya aiki a kan wasu ƙwayoyin ƙwayoyin cuta ko tsarin mai juyayi. Wannan hujja tana bayyana dalilin da yasa take da karancin halayen illa.

Orlistat

Dukansu Lorcaserin da jerin sunayen suna taimakawa cikin asarar nauyi. Koyaya, tsarin aikin su ya bambanta.
Kamar dai magidancin, Orlistat na ɗan lokaci yana hana leɓɓan ciki da na pancreatic. Wannan hanawa yana tsoma baki tare da maganin kwayar cutar triglycerides daga abincin mutum, saboda haka, dukkanin ƙwayoyin da ke cikin maye suna canzawa ba canzawa.
Dangane da gwajin gwaji na asibiti, batutuwa na ɗan adam na iya rasa nauyi da sauri yayin amfani da jerin sunayen fiye da waɗanda ke kan wuribo. A ƙarshen watanni shida, za a sami manyan canje-canje a kewayen kugu. Bayan wannan, shan maganin yana rage karfin jini da kuma kamuwa da cutar sikari irin na II.
Orlistat shine madaidaicin madaidaicin lorcaserin wanda ke samuwa azaman likitancin magani don magance kiba amma kuma zaka iya siyan kan-kan-counter. Ba kamar lorcaserin ba, wannan magani har yanzu yana kan mai farin kayan FDA. Yawancin jihohi zasu siyar da ƙarin ba tare da buƙatar ingantaccen takardar sayan magani ba. ,Auka, alal misali, a cikin Amurka, Tarayyar Turai, da Ostiraliya, sayen jerin gwano yana da sauƙi kamar biyan kuɗin takalmi. Orlistat ba shi da tasiri akan sauran enzymes na GIT ko tsarin juyayi.

A cikin komi

Ceilistat da jerin sunayen sune hanyoyin yin amfani da lorcaserin don magance kiba da kiba. Koyaya, ƙwarewar su zata ƙaru ne kawai tare da ayyukan motsa jiki da abinci mai ƙarancin kalori. Lorcaserin da jerin suna rage nauyi da girman kugu amma dakatar da maganin su zai sa mai amfani ya dawo da kashi 35% na abin da suka rasa.
Ya zuwa yanzu, kari ne kawai na Cetilistat wanda bai sanya shi ga likitan Amurka FDA ba tunda har yanzu yana cikin gwajin asibiti. Amma ga jerin sunayen, saye shi yafi kama da siyan kayan aikin ku na paracetamol. Sabanin haka, sayan lorcaserin ba shi yiwuwa tunda Hukumar Tarayyar Amurka ta soke amincewarta a farkon 2020.
Dukkanin kwayoyi uku suna aiki sosai amma cetilistat yana da sanannun sakamako. Bayan haka, yana da ƙananan sakamako masu illa kuma an jure shi da kyau a cikin jiki.


Inda zan Sayi Lorcaserin da matsakaita?

Kuna iya yin sayan lorcaserin a shagunan yanar gizo. Ana samun foda a cikin yawa don masu bincike da manazarta. Lokacin da burin ku ya rasa ƙarin fam saboda kiba, zaku iya bincika lorcaserin don siyarwa akan layi. Koyaya, zaku iya buƙatar takardar sayan magani sakamakon tsayayyun jagororin da FDA.
Idan kuna neman lorcaserin ko tsaka-tsakinsu, yakamata ku shiga tare da CMOAPI don ingantaccen kayan samfuran. Ma'aikatanmu sun sami tabbacin inganci.


References
  1. Taylor, J., Dietrich, E., da Powell, J. (2013). Lorcaserin don Gudanar da nauyi. Ciwon sukari, Ciwon Cutar Magani, da Kiba.
  2. Hoy, SM (2013). Lorcaserin: Nazarin Amfani da shi a cikin Kulawar Weight. Kwayoyi.
  3. Hess, R., da Gicciye, LB (2013). Tsaro da Ingancin Lorcaserin a cikin Gudanar da Kiba. Postgraduate Medicine.
  4. Brashier, DB, Sharma, AK, Dahiya, N., da Singh, SK (2014). Lorcaserin: Magungunan Antiobesity na Novel. Jaridar Pharmacology & Pharmacotherapeutics.
  5. Chan, EW et al. (2013). Inganci da Tsaro na Lorcaserin a cikin Manya Manya: Meta-Analysis na 1-shekara Randomized Control Trials (RCTs) da Rarraba Nazari akan Short-Term RCTs. Bayanan kiba.
  6. Nigro, SC, Luon, D., da Baker, WL (2013). Lorcaserin: Wani Labari na Serotonin 2C Agonist don Kula da Kiba. Binciken Nazarin Lafiya na Yanzu da Ra'ayi.